What is the scope of the problem:
Early detection of ongoing hemorrhage (OH) before onset of shock is a universally acknowledged great unmet need, and particularly important after acute traumatic and non-traumatic hemorrhage.
Delays in the detection of OH are associated with a “failure to rescue” and a dramatic deterioration in prognosis once the onset of clinically frank shock has occurred.
Current techniques and technologies for early detection of occult OH are inadequate in a variety of situations both in resource austere conditions and in advanced clinical centers